Biktarvy (Bictegravir Emtricitabine Tenofovir)

Description

What is Biktarvy?

Biktarvy is a fixed-dose combination medication that contains three active ingredients: bictegravir, emtricitabine, and tenofovir alafenamide. It is indicated for the treatment of HIV-1 infection in adults and children aged 12 years and older who weigh at least 35 kg. Biktarvy works by inhibiting the replication of the HIV virus, helping to reduce viral load and improve immune function.

How does Biktarvy work in the body?

Biktarvy works through its three components:

• Bictegravir: An integrase strand transfer inhibitor (INSTI) that blocks the HIV integrase enzyme, preventing the virus from integrating its genetic material into the host cell’s DNA.
• Emtricitabine: A nucleoside reverse transcriptase inhibitor (NRTI) that interferes with the reverse transcription process, blocking the conversion of viral RNA into DNA.
• Tenofovir Alafenamide: Another NRTI that inhibits viral replication by interfering with reverse transcription and reducing the amount of virus in the body.

Together, these actions help to suppress the HIV virus effectively.

Who is Biktarvy for?

Biktarvy is intended for individuals diagnosed with HIV-1 infection who are in need of antiretroviral therapy. Candidates for Biktarvy therapy include:

• Adults with HIV-1: Those who are newly diagnosed or switching from another antiretroviral regimen.
• Pediatric Patients: Children aged 12 years and older who weigh at least 35 kg.

What are the benefits of using Biktarvy?

• Effective Viral Suppression: Biktarvy has been shown to effectively reduce viral load to undetectable levels in many patients.
• Single Tablet Regimen: The convenience of a once-daily single tablet simplifies adherence to treatment.
• Minimal Drug Interactions: Biktarvy has a favorable drug interaction profile compared to some other HIV medications.
• Improved Quality of Life: Effective management of HIV can lead to better overall health and quality of life for individuals living with the virus.

What are the side effects of Biktarvy?

While effective, Biktarvy may cause side effects in some individuals. Common side effects include:

• Diarrhea: Some users may experience gastrointestinal discomfort, including diarrhea.
• Nausea: Mild nausea can occur but usually resolves over time.
• Fatigue: Some individuals report feeling tired or fatigued while on this medication.
• Headache: Headaches are also a common side effect associated with antiretroviral therapy.

How should Biktarvy be taken / dosage information?

Biktarvy is typically taken orally as a single tablet. Key dosage information includes:

• Recommended Dose: The usual dose is one tablet (50 mg bictegravir/200 mg emtricitabine/10 mg tenofovir alafenamide) taken once daily.
• Administration: It can be taken with or without food; however, taking it consistently at the same time each day is important for optimal efficacy.

Who should avoid taking Biktarvy?

Certain individuals should avoid using Biktarvy:

• History of Severe Allergic Reactions: Those with known hypersensitivity to any component of Biktarvy should not use this medication.
• Severe Liver Disease: Individuals with liver impairment should consult their healthcare provider before starting treatment.