Otezla (Apremilast)

Description

What is Otezla?

Otezla is an oral medication that contains the active ingredient apremilast, which is classified as a phosphodiesterase 4 (PDE4) inhibitor. It is primarily used to manage moderate to severe plaque psoriasis in adults and to treat active psoriatic arthritis.

How does Otezla work in the body?

Otezla works by inhibiting the enzyme PDE4, which plays a role in the inflammatory response:

• Reduction of Inflammation: By inhibiting PDE4, Otezla decreases the production of pro-inflammatory cytokines, leading to reduced inflammation and improved skin and joint symptoms.
• Improvement of Symptoms: This action helps alleviate symptoms associated with psoriasis and psoriatic arthritis, such as redness, scaling, and joint pain.

Who is Otezla for?

Otezla is intended for adults with moderate to severe plaque psoriasis or active psoriatic arthritis who may benefit from systemic therapy. Candidates for Otezla therapy include:

• Individuals with Plaque Psoriasis: Those experiencing significant skin symptoms that affect their quality of life.
• Patients with Psoriatic Arthritis: Individuals suffering from joint pain and swelling related to psoriatic arthritis.

What are the benefits of using Otezla?

• Effective Symptom Control: Many users experience significant improvements in skin condition and joint symptoms.
• Convenient Dosing: Administered as an oral tablet taken twice daily, making it easy to incorporate into daily routines.
• Minimal Risk of Serious Side Effects: Compared to some other systemic therapies, Otezla has a favorable safety profile.

What are the side effects of Otezla?

While effective, Otezla may cause side effects in some individuals. Common side effects include:

• Gastrointestinal Issues: Nausea, diarrhea, and abdominal pain may occur.
• Headache: Some users report experiencing headaches while taking this medication.
• Weight Loss: Unintentional weight loss can occur in some individuals.
• Infections: There may be an increased risk of infections due to immune modulation.

How should Otezla be taken / dosage information?

Otezla is typically taken orally in tablet form. Key dosage information includes:

• Recommended Dose: The usual starting dose is 10 mg once daily for the first week, increasing to 20 mg once daily for the second week, and then 30 mg once daily thereafter.
• Administration: It can be taken with or without food; consistency in timing each day is important for optimal results.

Who should avoid taking Otezla?

Certain individuals should avoid using Otezla:

• History of Severe Allergic Reactions: Those with known hypersensitivity to apremilast or any components of the formulation should avoid this medication.
• Severe Renal Impairment: Individuals with significant kidney dysfunction should consult their healthcare provider before starting treatment.