Pentasa (Mesalazine)

Additional information

Pentasa (Mesalazine) is typically given once a day at bedtime. However, your doctor or pharmacist may have suggested a different schedule that is more appropriate for you. Lie on your left side with your right knee bent. Gently insert the lubricated applicator tip into the rectum (the last several inches of the large intestine closest to the anus), pointed slightly toward the navel (umbilicus). Grasp the bottle firmly, then tilt slightly so that the nozzle is aimed toward the back, and squeeze slowly to instill the medication. Remain in position for at least 30 minutes to allow thorough distribution of the medication internally. Important: Follow the instructions on the label. Do not use more of this product, or more often, than prescribed. If you forget a dose, contact your pharmacist.

WARNING: Use with caution in patients predisposed to cardiac (heart) allergic reactions. Monitor for signs and symptoms of hypersensitivity (allergy), discontinue treatment for mesalamine-induced hypersensitivity (allergy reactions). Use with caution in patients with pre-existing skin conditions, avoid prolonged exposure to sunlight and ultraviolet light. Liver failure has been reported, kidney impairment has been reported. Good hydration is recommended. Use with caution in the elderly patients >65 years of age because it may lead to blood cell disturbances. Use with caution in patients with kidney and liver impairment. These events may occur at anytime during therapy and without warning.

In addition to its desired action, Pentasa (Mesalazine) may cause some side effects, notably:
It may cause stomach pain or cramps, gas, nausea, or vomiting.
It may cause increased urge to go to the bathroom, irritation of the rectal (the last several inches of the large intestine closest to the anus) area, or diarrhea. 
It may cause back pain, blood pressure changes, fatigue, or tiredness. 
It may cause acne, hair loss, or headache. 

Contraindications: Hypersensitivity (severe allergic reactions) to mesalamine, aminosalicylates, salicylates (such as aspirin), or any component of the formulation, severe kidney and liver impairment. Existing gastric (stomach ulcer, a sore on the lining of your stomach, small intestine or esophagus, urinary tract obstruction), use in children <2 years of age.

Taking Pentasa (Mesalazine) during pregnancy may be harmful for the baby. Women of childbearing potential should use an effective contraceptive method. Pregnant women should not use this product. If you're planning a pregnancy or become pregnant or breastfeeding, contact your family doctor.

A treatment with Pentasa (Mesalazine) requires regular monitoring by a doctor. Be sure to see your doctor for all regularly scheduled appointments.Pentasa (Mesalazine)