Dovato (Dolutegravir Lamivudine)

Description

What is Dovato?

Dovato is an oral medication that combines two active ingredients: dolutegravir and lamivudine. It is indicated for the treatment of HIV-1 infection in adults and children weighing at least 30 kg who are either starting HIV treatment or replacing their current regimen.

How does Dovato work in the body?

Dovato works by inhibiting different stages of the HIV life cycle:

• Dolutegravir: An integrase strand transfer inhibitor (INSTI) that blocks the HIV integrase enzyme, preventing the virus from integrating its genetic material into the host cell’s DNA.
• Lamivudine: A nucleoside reverse transcriptase inhibitor (NRTI) that interferes with the reverse transcription process, blocking the conversion of viral RNA into DNA.

Together, these actions help to suppress the HIV virus effectively.

Who is Dovato for?

Dovato is intended for individuals diagnosed with HIV-1 infection who are in need of antiretroviral therapy. Candidates for Dovato therapy include:

• Adults with HIV-1: Those who are newly diagnosed or switching from another antiretroviral regimen.
• Pediatric Patients: Children aged 12 years and older who weigh at least 30 kg.

What are the benefits of using Dovato?

• Effective Viral Suppression: Dovato has been shown to effectively reduce viral load to undetectable levels in many patients.
• Single Tablet Regimen: The convenience of a once-daily single tablet simplifies adherence to treatment.
• Minimal Drug Interactions: Dovato has a favorable drug interaction profile compared to some other HIV medications.
• Improved Quality of Life: Effective management of HIV can lead to better overall health and quality of life for individuals living with the virus.

What are the side effects of Dovato?

While effective, Dovato may cause side effects in some individuals. Common side effects include:

• Diarrhea: Some users may experience gastrointestinal discomfort, including diarrhea.
• Nausea: Mild nausea can occur but usually resolves over time.
• Fatigue: Some individuals report feeling tired or fatigued while on this medication.
• Headache: Headaches are also a common side effect associated with antiretroviral therapy.

How should Dovato be taken / dosage information?

Dovato is typically taken orally as a single tablet. Key dosage information includes:

• Recommended Dose: The usual dose is one tablet (50 mg dolutegravir/300 mg lamivudine) taken once daily.
• Administration: It can be taken with or without food; however, taking it consistently at the same time each day is important for optimal efficacy.

Who should avoid taking Dovato?

Certain individuals should avoid using Dovato:

• History of Severe Allergic Reactions: Those with known hypersensitivity to dolutegravir, lamivudine, or any components of the formulation should not use this medication.
• Severe Liver Disease: Individuals with liver impairment should consult their healthcare provider before starting treatment.