Janumet XR (Sitagliptin Metformin extended-release)

Description

What is Janumet XR?

Janumet XR is a fixed-dose combination medication that contains two active ingredients: sitagliptin, a DPP-4 inhibitor, and metformin, a biguanide. It is primarily used to improve glycemic control in adults with type 2 diabetes, particularly for those who require additional help managing their blood sugar levels.

How does Janumet XR work in the body?

Janumet XR works through its two components:

• Sitagliptin: Inhibits the DPP-4 enzyme, increasing the levels of incretin hormones that stimulate insulin release and decrease glucose production by the liver.
• Metformin: Reduces glucose production in the liver and improves insulin sensitivity, helping the body utilize glucose more effectively.

Together, these actions help lower blood sugar levels and improve overall glycemic control.

Who is Janumet XR for?

Janumet XR is intended for adults with type 2 diabetes who require additional glycemic control. Candidates for Janumet XR therapy include:

• Individuals with Type 2 Diabetes: Those who have not achieved adequate control through diet and exercise alone.
• Patients with Cardiovascular Risk Factors: Individuals who may benefit from improved glycemic control to reduce cardiovascular risks.

What are the benefits of using Janumet XR?

• Effective Blood Sugar Control: Helps lower blood sugar levels effectively when used alongside diet and exercise.
• Convenient Dosing: Typically taken once daily, making it easy to incorporate into daily routines.
• Minimal Risk of Hypoglycemia: When taken alone, Janumet XR has a low risk of causing low blood sugar.

What are the side effects of Janumet XR?

While effective, Janumet XR may cause side effects in some individuals. Common side effects include:

• Gastrointestinal Issues: Nausea, vomiting, diarrhea, and abdominal discomfort may occur.
• Headache: Some users report experiencing headaches while on this medication.
• Upper Respiratory Infections: Symptoms such as sore throat or nasal congestion may be experienced.

How should Janumet XR be taken / dosage information?

Janumet XR is typically taken orally in tablet form. Key dosage information includes:

Recommended Dose: The usual starting dose is 50 mg/1000 mg (sitagliptin/metformin) taken once daily. Depending on individual needs and kidney function, doses may vary.

Administration: It should be taken with food to help reduce gastrointestinal side effects.

Who should avoid taking Janumet XR?

Certain individuals should avoid using Janumet XR:

• History of Severe Allergic Reactions: Those with known hypersensitivity to sitagliptin or metformin should avoid this medication.
• Severe Kidney Impairment: Individuals with significant renal dysfunction should consult their healthcare provider before starting treatment.